do maart 31, 2011 10:46 am
Wikipedia schreef:5-Iodo-2-aminoindane (5-IAI) is a drug which acts as a releasing agent of serotonin, norepinephrine, and dopamine.[1] It was developed in the 1990s by a team led by David E. Nichols at Purdue University.[2] 5-IAI fully substitutes for MDMA in rodents and is a putative entactogen in humans.[2] Unlike related aminoindane derivatives like MDAI and MMAI, 5-IAI causes some serotonergic neurotoxicity in rats, but is substantially less toxic than the its corresponding amphetamine homologue pIA, with the damage observed barely reaching statistical significance.[1]
The reason 5-IAI is less neurotoxic than amphetamines is likely due to it lacking the toxic metabolites of the class (like nasty alpha-methyldopamine) which normally severely aggravate the damage. This is because it's an aminoindane instead of phenethylamine and is therefore markedly different on a structural level -- it either does not reduce to the corresponding damaging metabolites or it still does but they are no longer active. You can see the same thing going on with 4-methylaminorex here, potent releaser but little to no neurotoxicity.
do maart 31, 2011 6:56 pm
Contains: A Proprietary blend of high purity MDAI, 5-IAI and 2AI
wo maart 28, 2012 7:45 pm
zo apr 01, 2012 5:00 pm