Alfolenic Acid - AFA / WIN 25,978
Geplaatst: di jan 27, 2015 2:33 pm
Nieuwe research chemical. ff snel copy paste van wikipedia. Lijkt me interessant. Zal zsm. updaten.
Amfonelic acid (AFA; WIN 25,978) is a research chemical with highly selective dopaminergic stimulant and antibiotic properties.[1]
In studies it proved to be a potent and highly selective dopamine reuptake inhibitor (DRI) in rat brain preparations.[2][3] A study found a moderately long half-life of approximately 12 hours and a dopaminergic potency approximately 50 fold that of methylphenidate in rat brain preparations.[4] Despite lack of direct serotonin activity, rats treated with subchronic doses of amfonelic acid display subsequent decreases in 5HT and 5HIAA.[5] Amfonelic acid displays no activity in the norepinephrine system.[6]
Despite a greatly different mechanism of action, amfonelic acid displays discriminatory substitution with 150% the stimulant potency of dextroamphetamine.[7]
Amfonelic acid has been shown to be neuroprotective against methamphetamine damage to dopamine neurons.[8] It also increases the effects of the antipsychotic drugs haloperidol, trifluoperazine and spiperone.[9]
Rats are shown to self-administer amfonelic acid in a dose-dependent manner, thus it may have recreational abuse potential in humans.[10]
Amfonelic acid (AFA; WIN 25,978) is a research chemical with highly selective dopaminergic stimulant and antibiotic properties.[1]
In studies it proved to be a potent and highly selective dopamine reuptake inhibitor (DRI) in rat brain preparations.[2][3] A study found a moderately long half-life of approximately 12 hours and a dopaminergic potency approximately 50 fold that of methylphenidate in rat brain preparations.[4] Despite lack of direct serotonin activity, rats treated with subchronic doses of amfonelic acid display subsequent decreases in 5HT and 5HIAA.[5] Amfonelic acid displays no activity in the norepinephrine system.[6]
Despite a greatly different mechanism of action, amfonelic acid displays discriminatory substitution with 150% the stimulant potency of dextroamphetamine.[7]
Amfonelic acid has been shown to be neuroprotective against methamphetamine damage to dopamine neurons.[8] It also increases the effects of the antipsychotic drugs haloperidol, trifluoperazine and spiperone.[9]
Rats are shown to self-administer amfonelic acid in a dose-dependent manner, thus it may have recreational abuse potential in humans.[10]