4-FMP - Wat is het nou eigelijk?
Geplaatst: do feb 13, 2014 12:44 am
Dat de schade van 4-FMP wel meevalt begint al een beetje te bezinken:
"All three 4-haloamphetamines reduced the activity of tryptophan hydroxylase and lowered the levels of serotonin and 5-hydroxyindoleacetic acid in the whole brain initially. With 4-chloroamphetamine and 4-bromoamphetamine, the depletion lasted for at least a week. 4-fluoroamphetamine, in contrast, lowered serotonin and 5-hydroxyindole acid levels for only short times (2-6 hr) after drug injection, and 5-hydroxyindole levels were essentially back to normal within 24 hr. [..] The failure of 4-fluoroamphetamine to produce a long-lasting depletion of brain serotonin like that produced by 4-chloroamphetamine or 4-bromoamphetamine may reflect the inability of the fluoro-compound to be metabolized in the same way."
En tevens, daaropvolgend:
"4-fluoroamphetamine lowers serotonin initially to about the same degree as 4-chloro-amphetamine at the 0.1 mmol/kg dose, but the effect is transient. This finding indicates that 4-fluoroamphetamine shares with the 4-chloroamphetamine the action that is responsible for the short term [serotonin] depletion but lacks the property required for the long term effect. Perhaps a neurotoxic metabolite can be formed from 4-chloro and 4-bromo amphetamines but not from 4-fluoroamphetamine."
Beide uit de volgende studie:
R.W. Fuller, J.C. Baker, K.W. Perry, B.B. Molloy, Comparison of 4-chloro-, 4-bromo- and 4-fluoroamphetamine in rats: Drug levels in brain and effects on brain serotonin metabolism, Neuropharmacology, Volume 14, Issue 10, October 1975, Pages 739-746, ISSN 0028-3908, http://dx.doi.org/10.1016/0028-3908(75)90099-4.
(http://www.sciencedirect.com/science/article/pii/0028390875900994)
Wat het precies doet om het effect te geven zijn we ook al achter:
4-fluoroamphetamine is a releasing agent and reuptake inhibitor of dopamine, serotonin, and norepinephrine.
(http://en.wikipedia.org/wiki/4-Fluoroamphetamine)
Maar wat is het nou eigelijk precies?? 4-Fluoroamphetamine? Fluor? Amphetamine? Wat voor Fluor spreken we hierover, hoe komt dit op de Amphetamine, hoe wordt dit gemaakt? Vind het nogal mysterieus dat er nergens iemand credits krijgt voor het als eerst synthetiseren van deze drug.
Verder ideaal stofje, geen inslag, geen sjembek, geen crash, geen dip, geen bullshit
"All three 4-haloamphetamines reduced the activity of tryptophan hydroxylase and lowered the levels of serotonin and 5-hydroxyindoleacetic acid in the whole brain initially. With 4-chloroamphetamine and 4-bromoamphetamine, the depletion lasted for at least a week. 4-fluoroamphetamine, in contrast, lowered serotonin and 5-hydroxyindole acid levels for only short times (2-6 hr) after drug injection, and 5-hydroxyindole levels were essentially back to normal within 24 hr. [..] The failure of 4-fluoroamphetamine to produce a long-lasting depletion of brain serotonin like that produced by 4-chloroamphetamine or 4-bromoamphetamine may reflect the inability of the fluoro-compound to be metabolized in the same way."
En tevens, daaropvolgend:
"4-fluoroamphetamine lowers serotonin initially to about the same degree as 4-chloro-amphetamine at the 0.1 mmol/kg dose, but the effect is transient. This finding indicates that 4-fluoroamphetamine shares with the 4-chloroamphetamine the action that is responsible for the short term [serotonin] depletion but lacks the property required for the long term effect. Perhaps a neurotoxic metabolite can be formed from 4-chloro and 4-bromo amphetamines but not from 4-fluoroamphetamine."
Beide uit de volgende studie:
R.W. Fuller, J.C. Baker, K.W. Perry, B.B. Molloy, Comparison of 4-chloro-, 4-bromo- and 4-fluoroamphetamine in rats: Drug levels in brain and effects on brain serotonin metabolism, Neuropharmacology, Volume 14, Issue 10, October 1975, Pages 739-746, ISSN 0028-3908, http://dx.doi.org/10.1016/0028-3908(75)90099-4.
(http://www.sciencedirect.com/science/article/pii/0028390875900994)
Wat het precies doet om het effect te geven zijn we ook al achter:
4-fluoroamphetamine is a releasing agent and reuptake inhibitor of dopamine, serotonin, and norepinephrine.
(http://en.wikipedia.org/wiki/4-Fluoroamphetamine)
Maar wat is het nou eigelijk precies?? 4-Fluoroamphetamine? Fluor? Amphetamine? Wat voor Fluor spreken we hierover, hoe komt dit op de Amphetamine, hoe wordt dit gemaakt? Vind het nogal mysterieus dat er nergens iemand credits krijgt voor het als eerst synthetiseren van deze drug.
Verder ideaal stofje, geen inslag, geen sjembek, geen crash, geen dip, geen bullshit