Jimscaline
Geplaatst: za mei 10, 2014 6:50 pmKwam deze stof toevallig tegen, wel een toffe naam.
Maar zoals ik eerst dacht inderdaad 'familie' van het bekendere Mescaline.
Ik zet hier een kopie neer van wat ik bij toeval op de engelstalige wiki vond
Jimscaline.png
Systematic (IUPAC) name
(R)-(2,3-dihydro-4,5,6-trimethoxy-1H-inden-1-yl)aminomethane
Clinical data
Legal status
Uncontrolled
Routes
Oral
Identifiers
CAS number
890309-57-6
ATC code
None
PubChem
CID 11673493
ChemSpider
9848222
Chemical data
Formula
C13H19NO3
Mol. mass
237.294 g/mol
SMILES[show]
InChI[show]
(what is this?) (verify)
Jimscaline (C-(4,5,6-trimethoxyindan-1-yl)methanamine) is a conformationally-restricted derivative of the cactus-derived hallucinogen mescaline, which was discovered in 2006 by a team at Purdue University led by David E. Nichols. It acts as a potent agonist for the 5-HT2A and 5-HT2C receptors with the more active (R)-enantiomer having a Ki of 69 nM at the human 5-HT2A receptor, and around three times the potency of mescaline in drug-substitution experiments in animals.[1] This discovery that the side chain of the phenethylamine hallucinogens could be constrained to give chiral ligands with increased activity then led to the later development of the super-potent benzocyclobutene derivative TCB-2.[2][3]
Maar zoals ik eerst dacht inderdaad 'familie' van het bekendere Mescaline.
Ik zet hier een kopie neer van wat ik bij toeval op de engelstalige wiki vond
Jimscaline.png
Systematic (IUPAC) name
(R)-(2,3-dihydro-4,5,6-trimethoxy-1H-inden-1-yl)aminomethane
Clinical data
Legal status
Uncontrolled
Routes
Oral
Identifiers
CAS number
890309-57-6
ATC code
None
PubChem
CID 11673493
ChemSpider
9848222
Chemical data
Formula
C13H19NO3
Mol. mass
237.294 g/mol
SMILES[show]
InChI[show]
(what is this?) (verify)
Jimscaline (C-(4,5,6-trimethoxyindan-1-yl)methanamine) is a conformationally-restricted derivative of the cactus-derived hallucinogen mescaline, which was discovered in 2006 by a team at Purdue University led by David E. Nichols. It acts as a potent agonist for the 5-HT2A and 5-HT2C receptors with the more active (R)-enantiomer having a Ki of 69 nM at the human 5-HT2A receptor, and around three times the potency of mescaline in drug-substitution experiments in animals.[1] This discovery that the side chain of the phenethylamine hallucinogens could be constrained to give chiral ligands with increased activity then led to the later development of the super-potent benzocyclobutene derivative TCB-2.[2][3]