J Clin Psychiatry schreef:Despite the inherent limitations and heterogeneity of the extant MRI literature, our review suggests that therapeutic oral doses of stimulants decrease alterations in brain structure and function in subjects with ADHD relative to unmedicated subjects and controls. These medication-associated brain effects parallel, and may underlie, the well-established clinical benefits.
Source: http://www.psychiatrist.com/JCP/article ... n0908.aspx
JAMA Psychiatry schreef:The meta-regression analysis for attention showed that long-term stimulant medication use (for periods ranging from 6 months to 3 years) was associated with more normal right but not left caudate function, and this survived age correction. The results parallel previous meta-analysis findings of normal right caudate structure in a similar location (Talairach x, y, and z coordinates of 16, 2, and 20) in patients with long-term medication relative to never-medicated patients and controls.37 Together, they suggest a right-lateralized positive plastic effect of long-term stimulant medication use on basal ganglia structure and function. The gradual normalization of right caudate function with long-term stimulant medication use may also be related to meta-analytic positron emission tomography findings of higher striatal dopamine transporter levels in patients with long-term medication use relative to controls and medication-naive patients, who had reduced striatal dopamine transporter levels relative to controls.107 The right-lateralized effect may also explain why long-term stimulant medication use did not normalize the abnormal caudate function in the meta-regression analysis of the inhibition tasks, which was left hemispheric, as is typical for motor inhibition tasks.6,12 Furthermore, a right-lateralized effect would be in line with the trend-level finding toward an association between long-term stimulant medication use and more normal right caudate activation in the interference inhibition tasks, which may not have reached statistical significance due to lack of power. This would also echo evidence that methylphenidate has a stronger effect on right basal ganglia blood flow and metabolism, rather than left.108,109
Source: http://archpsyc.jamanetwork.com/article ... id=1485446
Wiley Online Library schreef:Basal ganglia regions like the right globus pallidus, the right putamen, and the nucleus caudatus are structurally affected in children with ADHD. These changes and alterations in limbic regions like ACC and amygdala are more pronounced in non-treated populations and seem to diminish over time from child to adulthood. Treatment seems to have positive effects on brain structure.
Source: http://onlinelibrary.wiley.com/doi/10.1 ... x/abstract
Deze post is om de discussie nog wat aan te wakkeren, want ik ben van mening dat men ADHD als een serieus iets moet zien, al wordt het wel vaak te snel en daardoor onterecht gediagnosticeerd (daar ben ik het wel mee eens.)
