Codeïne - algemene informatie

Einstein schreef:Dan zou de omzetting juist minder efficiënt verlopen, als je het enzym remt dat nodig is om die omzetting tot morfine voor elkaar te boksen.

CYP2D6 Inducers:

Carbamazepine: Anticonvulsant and mood stabilizer. (Schedule 4)

Dexamethasone: Glucocorticoid steroid. (Schedule 4)

Ethanol: AKA alcohol, beware drinking too much and experiencing side-effects such as severe nausea or CNS depression. One or two standard drinks 45 minutes before the codeine should work.

Phenobarbital: Barbiturate, be careful if you try this due to the risk of CNS depression. If used, lower your standard dose of both substances to be safe. (Schedule 4, wasn't in the TGA Posion Standard 2008 document but wikipedia says schedule 4)

Phenytoin: Antiepileptic, also used in treatment of neuralgia and arrhythmia. (Schedule 4)

Primidone: Anticonvulsant and pro-drug for phenobarbital. Exercise due caution as with phenobarbital. (Schedule 4)

Rifampin: Antibiotic. This drug is known for hepatotoxicity and so users combining this with codeine from a CWE should be careful here and those with liver problems should probably avoid. (Couldn't find schedule as yet, will look further, given the rest barring grog and St John's Wort are schedule 4 its probably a safe bet this one is too)

Ritonavir: Antiretroviral used in treatment of HIV/AIDS. NOTE: DXM is probably best avoided being used in conjunction with Ritonavir. (Schedule 4)

St John's Wort: Herbal supplement that is sometimes used for depression. NOTE: As St John's Wort is supposed to be an MAOI it is best avoided if you take certain medicines. DXM may interact badly with it, as well as SSRI's. This is one there is a chance I might not experiment with, because I always try avoid MAOI's.

Taking any of these substances will theoretically increase the amount of codeine that is converted into morphine; a quick cross check with the TGA Poisons Standard 2008 shows that most of these are scheduled aside from ethanol and St John's Wort.

Ivo schreef:Codeïne met bier zorgt bij mij voor blackouts

Speed schreef:Hoelang houd het effect van codeïne ongeveer aan?

NorthernLightBE schreef:Leuk voor af en toe..soort van unieke suf maar niet echt meer dan dat.
Valt het te vergelijken met opium?

wiki schreef:Oripavine is an opiate and the major metabolite of thebaine. It is the parent compound from which a series of semi-synthetic opioids are derived, which includes the compounds etorphine and buprenorphine. Although its analgesic potency is comparable to morphine, it is not used clinically due to its severe toxicity and low therapeutic index.

Radical schreef:In het topic staat dat 7% van de mensen niet het enzym (CYP2D6) hebben. Maar volgensmij hebben maar 7% van de mensen dit wel. En de andere 93% niet.

Italiano schreef:

Radical schreef:In het topic staat dat 7% van de mensen niet het enzym (CYP2D6) hebben. Maar volgensmij hebben maar 7% van de mensen dit wel. En de andere 93% niet.

De prevalentie van slow metabolizers (codeine naar morfine) onder blanken is tussen de 7 en 10 procent. Wat jij zegt klopt niet.

prototype schreef:Laatst 80mg geprobeerd.
Zo'n halfuur lang had ik een beetje het gevoel alsof ik weinig wiet gerookt had, daarna was ik alleen ongeconcentreerd & dromerig.