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Gevaren veilige dosis MDMA in warme omgeving

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Gevaren veilige dosis MDMA in warme omgeving

Berichtdoor Claviceps » wo jun 18, 2014 12:28 pm

A moderate dose of MDMA, commonly known as Ecstasy or Molly, that is typically nonfatal in cool, quiet environments can be lethal in rats exposed to conditions that mimic the hot, crowded, social settings where the drug is often used by people, a study finds. Scientists have identified the therapeutically-relevant cooling mechanism to enable effective interventions when faced with MDMA-induced hyperthermia.

The study, publishing tomorrow in the Journal of Neuroscience, was conducted by researchers at the National Institute on Drug Abuse’s Intramural Research Program (NIDA IRP). NIDA is a part of the National Institutes of Health.

While MDMA can have a range of adverse health effects, previous studies have shown that high doses of MDMA increase body temperature, while results with moderate doses were inconsistent. This has led some people to assume that the drug is harmless if taken in moderation. However, this study shows that in rats even moderate doses of MDMA in certain environments can be dangerous because it interferes with the body’s ability to regulate temperature.

“We know that high doses of MDMA can sharply increase body temperature to potentially lead to organ failure or even death,” said NIDA Director Dr. Nora D. Volkow. “However, this current study opens the possibility that even moderate doses could be deadly in certain conditions.”

It is impossible to predict who will have an adverse reaction even to a low dose of MDMA. However, in this study scientists gave the rats low to moderate doses that have been shown in past studies to not be fatal. They monitored the rats to determine drug-induced changes in brain and body temperature and in the body’s ability to cool itself through blood vessel dilation. When rats were alone and in a room-temperature environment, a moderate dose of MDMA modestly increased brain and body temperature and moderately diminished the rats’ ability to eliminate excessive heat. However, when researchers injected the same dose in rats that were either in a warmer environment or in the presence of another rat in the cage, brain temperature increased, causing death in some rats. These fatal temperature increases were because the drug interfered with the body’s ability to eliminate heat.

“These results demonstrate that the use of MDMA in certain warm, social settings could be more dangerous than commonly believed,” said Dr. Eugene Kiyatkin, first author on the study and NIDA IRP scientist. “Even with moderate doses, we saw drug-induced, fatal brain hyperthermia during conditions of social interaction and in warm environments.”

These findings further suggest that medical interventions aimed at increasing the efficiency of whole-body cooling by targeting blood vessel constriction in the skin could be therapeutically relevant for counteracting the development of MDMA-induced hyperthermia.

Bron: http://www.drugabuse.gov/news-events/ne ... vironments
Abstract Paper: Critical Role of Peripheral Vasoconstriction in Fatal Brain Hyperthermia Induced by MDMA (Ecstasy) under Conditions That Mimic Human Drug Use
“Scientists do not speak in absolutes, they present the results that support the hypothesis and the tolerance for error.”
Claviceps
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Re: Gevaren veilige dosis MDMA in warme omgeving

Berichtdoor Perry » wo jun 18, 2014 12:55 pm

Best interessant, maar ik geloof dat de mens een veel geavanceerder intern milieu heeft en het voor heel wat meer doden gezorgd zou hebben als dit echt zo erg zou zijn.
Wat ik wel denk is dat t voor wat extra hersenschade zorgt, maar dat is ook wel logisch eigenlijk
Bennaccio schreef:werkt een Fool als antidepressiva?

Hoe vind je zelf dat het gaat?
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Re: Gevaren veilige dosis MDMA in warme omgeving

Berichtdoor Miss E » wo jun 18, 2014 1:43 pm

a moderate nontoxic dose (9 mg/kg or ∼1/5 of LD50)

"Moderate"? :s
Vind het niet gek dat er ratten zijn gestorven zijn met deze hoge dosis. Vraag me ook af of de ratten water tot hun beschikking hadden, een belangrijke manier om jezelf af te kunnen koelen.

Ik ben benieuwd naar het artikel!
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Re: Gevaren veilige dosis MDMA in warme omgeving

Berichtdoor Schepje » wo jun 18, 2014 1:52 pm

Volgens mij zit dat omgerekend net onder de 2mg/kg.
Kan zelfs lager liggen.
http://www.erowid.org/chemicals/mdma/md ... stry.shtml

De ld50 ligt ong 5x hoger.
Laatst bijgewerkt door Schepje op wo jun 18, 2014 1:54 pm, in totaal 3 keer bewerkt.
Endorfine junky,
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Re: Gevaren veilige dosis MDMA in warme omgeving

Berichtdoor Miss E » wo jun 18, 2014 1:53 pm

Wat omgerekend? 9 mg/kg = 9 mg/kg

Edit: je hebt gelijk inderdaad, onze LD50 ligt waarschijnlijk lager dan dat van ratten, had ik even geen rekening mee gehouden.
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Re: Gevaren veilige dosis MDMA in warme omgeving

Berichtdoor Schepje » wo jun 18, 2014 2:01 pm

Die shit is wel voor het leven :P
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