Benzo Fury (6-APB)

SpeedY schreef:is er ondertussen nog nieuwe informatie over 6-APB bekend geworden?
ik ben met name geinteresseerd in lange termijn effecten en andere schadelijke effecten/risico's, aangezien ik deze stof tegenwoordig standaard gebruik ipv mdma.

ik gebruik het soms iets te frequent, maar buiten het feit om dat de space iets "normaler" aanvoelt dan de 1e keren, heb ik nooit klachten tijdens/na gebruik ervaren.
ook een kater is nauwelijks aanwezig naar mijn idee.

desondanks is alle info welkom!

Toxicity and harm potential

Due to only having a short history of human use, the toxicity and harm potential is not exactly known. Due to its simularity to MDMA, it is likely that the administration of repeated or high dosages of 6-APB can be neurotoxic and cardiotoxic[3][4] in some form.

The exact toxic dosage is unknown. It is strongly recommended that one use harm reduction practices when using this drug.

Short-term health concerns

Short-term physical health risks of 6-APB consumption include dehydration, insomnia, and hyperthermia.[5] Continuous activity without sufficient rest or rehydration may cause body temperature to rise to dangerous levels, and loss of fluid via excessive perspiration puts the body at further risk as the stimulatory and euphoric qualities of the drug may render the user oblivious to their energy expenditure for quite some time. Diuretics such as alcohol may exacerbate these risks further, although this is known to be more of a problem for MDMA than it is 6-APB.

Although it has not been formally studied, like with MDMA, small changes in ambient temperature may cause large changes in 6-APB-induced serotonin neurotoxicity and core body temperature in the rat.[6][7]

Long-term health concerns

The neurotoxicity of 6-APB is controversial. It was specifically designed to be less neurotoxic than MDA or MDMA by circumventing the production of certain metabolic byproducts thought to underlie their toxicity (specifically alpha-methyl-dopamine).[citation needed] Although it is likely to be physically safe to try in a responsible context, it is completely possible that the administration of repeated or high dosages of 6-APB could result in neurotoxicity in some form, possibly manifesting as deficits in cognitive, affective and psychomotor function.

As with MDMA, long-term heavy use of 6-APB is likely cardiotoxic and thought to lead to valvulopathy through its actions on the 5-HT2B receptor.[8][9]

Tolerance and addiction potential

As with other stimulants, the chronic use of 6-APB can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

As a potent releaser of serotonin, tolerance builds quickly with prolonged and repeated use to the point that the drug eventually loses any positive effects and instead leaves the user in an uncomfortable state of anxious stimulation and dysphoria. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 21-30 days for the tolerance to be reduced to half and 2-3 months to be back at baseline (in the absence of further consumption). 6-APB presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of 6-APB all stimulants will have a reduced effect.

Dangerous interactions

Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

25x-NBOMe - Both the NBOMe series and this compound induce powerful stimulation and their interaction may cause severe side effects. These can include thought loops, seizures, increased blood pressure, vasoconstriction, increased heart rate, and heart failure (in extreme cases).
Alcohol - It is dangerous to combine alcohol, a depressant, with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of alcohol which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified disinhibition as well as respiratory depression. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
DXM - This combination may cause increased heart rate and panic attacks.
MXE - Increased heart rate and blood pressure may occur.
Tramadol - This combination can increase the risk of seizures.
MAOIs - This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants.[10]
Stimulants - The neurotoxic effects of 6-APB may be increased when combined with other stimulants.
Cocaine - This combination may cause unbearable combined strain on the heart, resulting in heart attack or stroke.

Serotonin syndrome risk

Combinations in the list below may increase the amount of neurotransmitters such as serotonin and dopamine to dangerous or even fatal levels.

MAOIs such as syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants[11]
Serotonin releasers such as MDMA, 4-FA, MDAI and αMT
Selective serotonin re-uptake inhibitors (SSRIs)
Serotonin-norepinephrine reuptake inhibitors (SNRIs)
5-HTP

There is an increased risk of serotonin syndrome when 6-APB is taken with many antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). Additionally, if 6-APB is taken with SSRIs and SNRIs, the 6-APB will be significantly less powerful or may have no distinguishable effects at all.

As with MDMA, long-term heavy use of 6-APB is likely cardiotoxic and thought to lead to valvulopathy through its actions on the 5-HT2B receptor

Amvitamientje schreef:322 nM [SERT], 1,997 nM [DAT], and 980 nM [NET]

JongGeleerd schreef:Dit is de affiniteit met de transporter, niet de afgifte

Dankjewel​ voor je snelle reactie, maar misschien had ik me beter moeten verwoorden. Ik bedoelde te zeggen dat ik het vroeg ivm gezondheid* en effect, aangezien er niets tot weinig informatie te vinden is over het combineren van 6-apb en AL-LAD. Ik bedoelde niet dat gezondheid de reden is dat ik deze twee verkies boven MDMA en LSD.

omerobert schreef:Wanneer was je laatste keer dat je bijvoorbeeld MDMA of 4-FA (of een andere serotonine releaser) hebt gebruikt voordat je 6-APB probeerde?

In mijn ervaring (en hoor dit ook vaak van anderen) is 6-APB hier nogal gevoelig voor namelijk. Voelde een keer een week na MDMA gebruik zo goed als niks van 150 mg, terwijl ik van dezelfde batch op 125 mg wel onder de indruk was, maar toen dus ook geen tolerantie had.